Can Magnetic Resonance Imaging of the Prostate Combined With a Radiomics Evaluation Determine the Invasive Capacity of a Tumour (Can MRI-PREDICT)
Prostate cancer is the most common cancer diagnosed in men in Canada. Magnetic resonance imaging (MRI) may become a valuable tool to non-invasively identify prostate cancer and assess its biological aggressiveness, which in turn will help doctors make better decisions about how to treat an individual patient's prostate cancer. Despite the promise of MRI for detecting and characterizing prostate cancer, there are several recognized limitations and challenges. These include lack of standardized interpretation and reporting of prostate MRI exams. The investigators propose to validate and improve a computer program computerized prediction tool that will use information from MR images to inform us how aggressive a prostate cancer is. The hypothesis is that this computer-aided approach will increase the reproducibility and accuracy of MRI in predicting the tumor biology information about the imaged prostate cancer.
⁃ An appropriate diagnostic MRI-P, defined as:
• Being performed on 3T MRI at the Halifax Infirmary Building
• Taken place within 5 weeks of study enrolment
• Having a detectable nodule which anatomically localizes to prostate cancer (PCa) identified in diagnostic biopsy specimen
• Acquired T1+contrast, T2, and attenuated diffusion coefficient (ADC) series axial images of the prostate
⁃ An appropriate diagnostic biopsy, defined as:
• Taken place within 2 months of the participant's MRI-P 1
• Taken place within 3 months of participant's study enrolment
• Reports diagnosis of PCa
• Reports a systematic assessment of the biopsy, assessing at least 12 cores
• Reports at least on core involved with PCa and this core must anatomically localise to a nodule seen on MRI-P 1